Sustainable Resources Dept.

isosorbide polycarbonate


The first step for bacteria to cause infection is the attachment to the host. As almost all of the bacteria in the natural world adhere to some solid surface and proliferate, they can become the source for an infection. Therefore, the development of materials that are less prone to bacterial adhesion seems to be useful for the prevention of infectious diseases. Since we found that some isosorbide polycarbonates repell bacteria, we investigated the influence of isosorbide concentration on the repellent effect. The number of attached bacteria, Staphylococcus aureus 209P and Escherichia coli K12, per per surface area decreased significantly(p<0.01) with increasing isosorbide polycarbonate mole fraction . It seems that the molar fraction of isosorbide polycarbonate changes the surface hydrophilicity and this, greatly influenced the first stage of biofilm formation of S. aureus 209P and E. coli K12.

Katsuhiko Hirota*1, Sasaki Haruo*2,Keitoku Fumio*3, Yoichiro Miyake*1,
  1. (*1)Departments of Oral Microbiology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8504, Japan.
  2. (*2)Mitsubishi Chemical Corporation Bioplastics Development Section Technology Center Performance Polymers Department 1, Toho-cho, Yokkaichi-shi, Mie 510-8530, Japan.
  3. (*3)Mitsubishi Chemical Corporation Advanced Product Laboratory R&D Center 1, Toho-cho, Yokkaichi-shi, Mie 510-8530, Japan.

Katsuhiko Hirota*1 “†Present Address: Department of Medical Hygiene, Dental Hygiene Course, Kochi Gakuen College (292-26 Asahitenjin-cho, Kochi 780-0955, Japan)”
Yoichiro Miyake*1 “†Present Address: Department of Oral Health Sciences, Faculty of Health and Welfare, Tokushima Bunri University (180 Nishihama-Boji Yamashiro-cho,Tokushima 770-8514, Japan)”


KOBUNSHI RONBUNNSHU(Japanese Journal of Polymer Science and Technology) Vol. 74 (2017) 6 p.631-634
Publisher; The Society of Polymer Science, Japan