- Mitsubishi Chemical Corporation
- Ion Exchange Resin Business Gr. Separation Materials Dept.
The Synthetic Adsorbents are cross-linked polymer spheres which provide specific surface area of 500-1200m2/dry-g with their porous structure. Available products include the aromatic-based HP series, the aromatic-based SP series, and the methacrylate ester-based HP2MGL. They are used for the adsorption purification of peptides, proteins, polyphenols, cephalosporin C, etc. as well as for the removal of bitter-tasting substances from fruit juices.
Created using special synthesis technology, the Synthetic Adsorbents are cross-linked polymer spheres which provide specific surface area of 500-1200m2/dry-g with their porous structure. The synthetic adsorbent material with its large porous surface area can adsorb many organic materials from solution using physical interaction between the surface and the adsorbed species.
Available product grades include the aromatic-based HP series, the SEPABEADS™ Series (aromatic-based SP800 series, aromatic-based SP70 series, aromatic-based SP700, modified aromatic-based SP207), and methacrylate ester-based HP2MGL. There is also a small diameter synthetic adsorbent material for chromatographic separation.
The synthetic adsorbent material's porous structure and principles may be compared to activated carbon, but comparing pore size, the synthetic adsorbent has larger 10-100 Angstrom pores that allow comparatively large organic molecules to be adsorbed. Therefore it is widely used for the purification of fermentation products such as antibiotics and for impurity removal.
Another comparison can be made with an alkyl-bonded silica gel adsorbent. The synthetic adsorbent material's chemical structure provides it with excellent durability in acidic and alkaline conditions. Therefore it works well with a wide range of adsorption and elution conditions. And it provides stable performance for a long period of time.
It is used for separation refining of pharmaceuticals, food, etc.
Lineup / Specifications
Aromatic-based HP Series
DIAION™ HP20・HP21are aromatic-based synthetic adsorbent materials. They were the first styrene-divinylbenzene-based synthetic adsorbent materials developed by our company. They feature pore size structure including pores large enough that peptides, proteins, polyphenols, etc. of molecular weight 1000 or more can undergo adsorption purification.
In addition, HP20 demonstrates superior separation performance as a filler in chromatography columns due to its extremely large pores including 260Å pore radius.
Aromatic-based SP800 Series
SEPABEADS™ SP825, SP850 are aromatic-based synthetic adsorption materials with large specific surface area of about 930m2/dry-g. They excel in adsorption refining of lower molecular weight molecules with molecular weight 1000 or less.
Its high specific surface area is especially utilized in the adsorption purification of cephalosporin C and the like which are manufactured by fermentation.
SEPABEADS™ SP70 is an aromatic-based synthetic adsorbent made with high purity materials (divinylbenzene:DVB). It complies with US FDA (United States Food and Drug Administration) regulations. Its moderate pore size results in excellent performance for adsorption of bitter substances like naringin from citrus fruit juice.
SEPABEADS™ SP700 is an aromatic-based synthetic adsorbent with medium pore size and large specific surface area (1200m2/dry-g). It shows outstanding performance in recovery of materials from fermentation solutions, in particular the extraction, concentration, and refining of pharmaceuticals and other valuable compounds.
This product has excellent elution characteristics and high adsorption performance because it has medium pore size and large surface area.
Modified Aromatic-based SP207
SEPABEADS™ SP207 is an aromatic-based synthetic adsorbent in which bromine has been incorporated into the aromatic ring. This provides excellent adsorption performance for highly hydrophilic organic molecules even though the pore surface is very hydrophobic.
In addition, because SP207 has high specific gravity, it is possible to perform batch processing with upward water flow.
Methacrylate Ester-based HP2MGL
DIAION™ HP2MGL is a highly hydrophilic methacrylate ester-based synthetic adsorbent, but it demonstrates high performance in extraction, concentration, and purification of highly hydrophobic organic compounds and proteins.
Using the difference between hydrogen bonding and hydrophobic bonding, it performs well as the adsorbent in chromatographic separation of natural substances.
In a special application, it is possible to refine fat-soluble substances such as tocopherols, using HP2MGL as the adsorbent in normal phase mode chromatographic separation.